Oxidative Stress and Dyslipidaemia in Type -2 Diabetic Patients Attending Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka.
Nwankwo, C. N.
MetadataShow full item record
Changes in oxidative stress parameters, lipid profile, atherogenic predictor indices, and anthropometrics of type 2 diabetes mellitus (T2DM) subjects attending Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH) Awka, were assessed using standard methods. Demographic data of the T2DM patients were collected with the aid of structured questionnaire.The subjects included willingly consented 60 (30 males and 30 females) T2DM patients and 40 (20 males and 20 females) apparently healthy, age-matched control subjects.GSH concentration, and activities of SOD, CAT and GPx decreased significantly (p<0.05), while MDA level increased significantly (p<0.05) in diabetics than in non-diabetics. The FBG concentration, lipid parameters (TC, TG, LDL-c and VLDL-c) and atherogenic indices (non HDL-c, CRI 1, CRI 11, AC and AIP) were significantly (p<0.05) higher in the diabetics, while HDL-c concentration was significantly decreased in diabetics compared to the controls. Majority of the diabetic subjects had abnormally high prevalence of dyslipidaemia and abnormally high levels of atherogenic predictor indices. The diabetics had significantly (p<0.05) higher BMI, WC, AC, WHR, WHtR, SBP and DBP than non-diabetics. FBG results of diabetics correlated positively with MDA (r2= 0.30, p=0.02) and non HDL-c (r=0.28; p=0.027), but negatively with GSH (r2= -0.30, p=0.04). Arm circumference had a weak negative correlation with GSH and CAT in the diabetics. BMI, WHtR, SBP and DBP were positively correlated with non HDL-c, CRI-I, CRI-II and AC, while AIP was positively correlated with BMI and WHtR. Diabetic males compared to females, were more educated, resident in urban areas, had higher comorbidity with hypertension, showed more signs of complications, had family history of diabetes and had over 10 years of suffering fromT2DM. On the other hand, female diabetics were involved in lower income occupation and practiced better nutritional regimen, but had significantly (p < 0.05) higher BMI, WC, WHR, SBP and DBP than the males. The results of this study have shown high occurrence of dyslipidaemia, oxidative stress and abnormality in atherogenic risk predictor indices among Nigerian T2DM patients. Correlation results indicate that MDA, non HDL-c and GSH are potentially important useful markers for the diagnosis and/or prognosis of diabetes. Adoption of a healthy dietary pattern should be encouraged in T2DM patients and intervention policies for effective management of T2DM should be sex specific.