A Comparative Study of the In Vitro Activities of Lactobacillus Acidophilus and Two Antifungal Agents on Candida Albicans
Anyanwu, G. O.
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The antifungal effect of Lactobacillus acidophilus probiotics against Candida albicans isolated from cases of recurrent vaginal candidiasis was investigated using standard microbiological procedures. All 250 isolates (100%) of C. albicans tested were susceptible (sensitive) to two broad spectrum antifungal agents, Nystatin and Fluconazole. The results of the testing of the C. albicans isolates showed that 240 of them (96%) were sensitive to the suspension of L. acidophilus probiotic with varying zones of inhibition at different concentrations. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the L. acidophilus suspensions showed higher inhibitory activity at the higher concentrations, with the maximum activity at 250 mg/ml. The commercial antifungal drugs were better than the suspension from the probiotic L. acidophilus. The results suggest that L. acidophilus could be a useful agent for development of antifungal against vaginal pathogens and may have great potential for use in external application and vaginal wash for preventing or reducing Candida growth.